Models

Novel 3D Flipwell system that models gut mucosal microenvironment for studying interactions between gut microbiota, epithelia and immunity

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Cell lines Caco-2 human colon epithelial cells were obtained from American Tissue Culture Collection (ATCC, CAT#: HTB-37, Manassas, VA). THP-1 human monocytic cells were obtained from ATCC (CAT#: TIB-202). HT29-MTX-E12 cells, mucous-secreting human intestinal cells, were obtained from Millipore Sigma (CAT#: 12040401, Burlington, MA). Bacillus subtilis (3A1T (wild-type)) strain was obtained from Bacillus Genetic Stock …

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A novel combination of triple immunotherapy improves antitumor responses in preclinical models of pancreatic cancer

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Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with a poor prognosis and limited treatment options. Researchers at Rutgers Cancer Institute of New Jersey, the state’s leading cancer program and the only National Cancer Institute-designated Comprehensive Cancer Center, along with RWJBarnabas Health, in collaboration with researchers at MD Anderson Cancer Center, have discovered a …

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Vincerx Pharma Presents Preclinical Data on VIP943 in Models of Acute Myeloid Leukemia at the 2022 American Society of Hematology 64th Annual Meeting.

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Vincerx’s proprietary carrier and linker technology and VIP943, a novel anti-CD123 antibody drug conjugate (ADC), demonstrated superiority with significantly improved safety in non-human primates (NHPs) compared to Mylotarg™ (gemtuzumab ozogamicin). VIP943 demonstrated monotherapy activity in ex vivo AML models and in vivo activity with significant tumor regression in combination with venetoclax and azacitidine …

Vincerx Pharma Presents Preclinical Data on VIP943 in Models of Acute Myeloid Leukemia at the 2022 American Society of Hematology 64th Annual Meeting. Read More »