lung

Trial of a new drug in KRAS-mutant lung cancer

A new study has just been launched that will study a new drug, VIC-1911, alone or given in combination with Lumakras (sotorasib) for patients with KRAS G12C-mutated non-small cell lung cancer (NSCLC), according to VITRAC Therapeutics, the maker of VIC-1911. VIC-1911 works by inhibiting the amplification or overexpression of the AURKA gene, which previous research …

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New cellular ‘switches’ found to fuel lung cancer growth, resistance to treatment

SCLC cell lines have divergent gene regulatory networks and phenotypes. (A) Hierarchical clustering was performed using 53 SCLC cell lines. Silhouette widths were calculated, which measure the similarity within each group. j, number of clusters; nI, number of samples in each cluster; aveSi, average silhouette width for each cluster. (B) Log fold change (FC) for …

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